Core Labs S-4 (Andarine, GTx-007)

Andarine (Andarine, S-4, GTx-007) - SARMs of the first generation. Effects of use: Increases muscle volume. Stimulates testosterone increase. Increases strength and endurance indicators. Has a lipolytic effect. Strengthens joints and ligaments. Can be used together with other SARMs or prohormones in different target courses. S-4 Core Labs Description Pharmacological group: SARM; SARM; selective androgen receptor modulators By its chemical properties, S-4 belongs to the class of chemical substances known as SARMs (SARM), or selective androgen receptor modulators. SARMs, like typical androgens, bind to androgen receptors and create selective anabolic activity in certain androgen receptors, hence their name. Compared to testosterone and other anabolic steroids and prohormones, the advantage of such SARMs as Andarine is that they do not have androgenic activity unrelated to bone and muscle tissues. S4 was developed for the treatment of such diseases as muscle loss, osteoporosis, and benign prostatic hyperplasia. The lead compound in the preparation is the non-steroidal androgen antagonist bicalutamide. Andarine is an orally applicable partial agonist of androgen receptors. S-4 is effective not only for maintaining existing muscle mass but also acts to increase it. Action of SARM Selective androgen receptor modulators (SARMs) bind to androgen receptors and demonstrate osteo- (bone) and myo- (muscle) anabolic activity. Binding and activation of androgen receptors change gene expression and increase protein synthesis, thus serving the purpose of muscle building. Thus, SARMs such as Andarine help muscle growth processes, essentially the same as steroids, but unlike testosterone and other anabolic steroids and prohormones, SARMs (as non-steroidal drugs) do not produce the effect of prostate and other secondary sexual organs growth. SARMs not only represent new opportunities for the treatment of a wide range of diseases, such as diseases associated with loss of muscle mass (ranging from the treatment of age-related diseases to the treatment of AIDS and cancer), they also have enormous potential for use in bodybuilding, fitness, and sports for the purpose of increasing muscle mass. S-4, in particular, binds to androgen receptors in muscles and bones one third as effectively as testosterone. S-4 Capabilities (Andarine) S-4 (at a dose of 3 mg/kg/day) is also able to restore skeletal muscles (for example, the cambal muscle) and strength in castrated rats, and can be used in the treatment of muscle atrophy, as well as in male hormonal therapy. A 120-day comparative study of the SARM S-4 and dihydrotestosterone (DHT) in ovariectomized rats showed that taking Andarine helped maintain bone mass and bone strength. The drug demonstrated overall higher efficacy compared to DHT. S-4 is also able to improve skeletal muscle strength, increase muscle mass, reduce fat deposits, and prevent bone loss. Testosterone causes a very similar increase in muscle mass and prostate growth depending on the dose, while S-4 shows a significant increase in muscle growth, but prostate growth remains largely uniform. Using S-4 (Andarine) Weight loss Fat loss is where S-4 truly excels. Some steroids, such as Winstrol and Anavar, help fight fat. They do not assume too much success in increasing muscle mass, but are very effective in weight loss. The properties of S-4 are very similar to the properties of such steroids. The presence of androgen receptors (AR) in human preadipocytes and adipocytes suggests that androgens can influence the control of adipose tissue development through the regulation of their own receptors. Since S-4 is close to AR, it demonstrates a similar fat burning effect. S-4 also reduces LPL (lipoprotein lipase), an enzyme that causes lipid accumulation. Andarine is also part of a group of drugs that, when combined with fat burning, promote muscle growth on a hypocaloric diet. One of the most frustrating results of weight loss is the loss of hard-earned muscle mass. Slowing down metabolism and hormone levels (T3, IGF, testosterone, etc.) due to lack of calories is the ideal catabolic environment for muscle tissue loss. Since S4 has both anabolic and androgenic effects on muscle tissue, it helps not only burn fat but also maintain and even increase muscle mass. S-4 is the cause of increased vascularity and contributes to a very good, "quality" muscle look, practically without retaining water. Thus, S-4 can be compared to Winstrol, but without the effect of sudden hair loss or extreme side effects on cholesterol levels. Other popular steroids/prohormones used for fat burning, such as Winstrol or Epistane, can cause joint drying. S-4 does not have such side effects, so athletes using it are able to lift heavy weights to maintain/increase muscle mass and strength. Another advantage of S-4 related to fat loss is that it does not cause heart pain, unlike other popular steroids/prohormones. Double effect (muscle mass increase plus fat loss) The double effect - fat loss and muscle mass increase - is what most users are looking for. Achieving this is extremely difficult if you are not a beginner in sports. One of the most important factors of the double effect is TIME. If you are trying to achieve multiple goals, you will need more time, even when using steroids. Moreover, you will most likely need to deal with the need for injections, as oral use of steroids/prohormones can have a detrimental effect on the liver, polluting it. Although S-4 is taken orally, it does not have a toxic effect on the liver, as it is not methylated, unlike other AAS/PH/DS compounds. It prevents such side effects and many others, and can be used for 6 weeks or more, which is a sufficient period of time to achieve noticeable results. Instructions for using S-4 to increase muscle mass and lose fat Doses of 50-75mg for 4-8 weeks provide a great double effect. The diet should also be optimized, with a slight increase in calories and at least 30% of the food should be protein. These positive effects can be enhanced by using the drug in combination with more anabolic SARMs, such as Ostarine. Strength and muscle mass increase Due to its androgenicity in muscle tissue, S-4 is a good means to increase strength and weight. Dosage of 50mg and higher is what is needed to achieve these goals. Also, due to the anabolic nature of the drug, strength increase will come along with successes in increasing muscle mass, although to a lesser extent than when using other, more anabolic SARMs, such as Ostarine. Also, like the orally administered steroid Anavar (Var), Andarine may not increase muscle mass as much as steroids such as Deca or Super-drol, but the muscle mass and strength accumulated during the cycle is maintained and not lost after the cycle ends. Since the half-life of Andarine is approximately 4 hours, it is recommended to divide the dose into several parts. Also, due to the short half-life, users have found that taking a dose before training helps increase performance in the gym. S-4 and estrogen SARMs cannot be aromatized, which is related to the effects of AR-connections consequences not metabolic conversion of active androgens/estrogens. Unlike Ostarine, where analysis showed a slight increase in serum estradiol levels, S-4 does not cause such an increase. Since it has a low androgenic activity, it has the opposite effect and reduces estrogen levels. This is evident when looking at the effects of S4 related to muscle strengthening. Benefits of S4 compared to steroids: - no need for pre-cycle support, such as taking hawthorn berries. - no need for cycle support, such as taking milk thistle for the liver, policosanol or rice for cholesterol control, etc. - at doses of 50mg and higher taken for more than 4 weeks, a suppression effect may be observed, however, strict post-cycle therapy, as with taking such SARMs as Nolva or Clomid, is not necessary. - high bioactivity when taken orally without significant liver damage, as in the case of oral administration of steroids/prohormones. - a sense of general well-being (without aggression, which can often have a detrimental effect on users in everyday life). - no need for a long break between cycles; the recommended time for a normal steroid cycle is the time of intake + therapy. For a typical 6-week cycle and 4 weeks of therapy, steroid users have to wait another 10 weeks after therapy before starting a new cycle. Side effects of S4 Although S-4 nullifies the above-mentioned side effects, there is one unique side effect associated with its use. When taken in doses of 50mg and higher, many users report visual disturbances. This effect is present only when using S-4 and quickly disappears once S-4 use is discontinued. Side effects caused by the M1 metabolite include night blindness and a slight yellowish tint in the eyes of some users. S-4: conclusions Has 1/3 the androgenicity in muscle tissue as testosterone. Anabolic at doses above 50mg. Helps develop strength and functional level. Excellent for developing muscle hardness. Excellent for improving blood supply, enhances pumping. Increases endurance (during aerobic and anaerobic loads). Accelerated fat loss at doses above 50mg. Overall effect of increased tone and body healing. Half-life is about 4 hours. Instructions for using S-4 (Andarine) Taking 50mg for 4-6 weeks is ideal for a fat burning cycle for most users. However, due to the weakening of the effects at this dosage, it is logical to use the drug on a 5*2 schedule, that is, use the drug for 5 days, then take a 2-day break, then repeat the five-day cycle. Take Andarine 2-3 times a day, in the morning, at noon, and in the evening, on an empty stomach. Показать полностью

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