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With thoughts of large, bulky muscles, everyone—especially the upcoming generation—is increasingly inclined toward building muscle mass. While a gym membership is one of the first steps, supplementing gym workouts with peptides and SARMs can help achieve results quickly. However, finding the right peptide or SARM to make your journey more rewarding than challenging isn’t always easy. Naturally, every compound you plan to use comes with its share of side effects, so making an informed choice is crucial. To simplify your decision, we’ll discuss one of the most potent SARMs—ACP-105! It’s gaining popularity with each passing day and seems a solid option for bodybuilding enthusiasts.
ACP-105 is a potent selective androgen receptor modulator (SARM) with enhanced affinity for skeletal muscles, initially developed for treating degenerative disorders but increasingly used in sports and fitness.
ACP-105 selectively binds to androgen receptors, reducing high-density lipoproteins, increasing muscle mass, and avoiding spikes in estrogen levels.
ACP-105 offers various benefits, including improved cognitive function, muscle growth without depletion, rapid recovery from injuries, stable energy, and reduced water retention.
ACP-105 promotes muscle mass growth by binding to skeletal muscles, enhancing both mass and endurance. The recommended dose is 1 mg/kg daily for 8–13 weeks.
User reviews indicate positive results with minimal side effects. Combining ACP-105 with other SARMs for cutting or bulking is advised, but caution is recommended due to potential side effects.
ACP-105, biochemically known as 2-chloro-4-[(1R,5R)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl]-3-methylbenzonitrile, is a potent selective androgen receptor modulator, widely known as a SARM (1).
SARMs are compounds with anabolic properties similar to androgenic drugs but with significantly fewer harmful effects.
Clinical trials have shown that ACP-105 has an enhanced affinity for skeletal muscles. Acadia Pharmaceuticals initially developed ACP-105 to assist with certain degenerative disorders. However, with increased research and development, its potential role in muscle building has led to its growing use in sports and fitness.
ACP-105, like many other SARMs, works by selectively binding to androgen receptors. This preferential binding ensures that ACP-105 avoids unnecessary effects on other vital organs in the body (2). Additionally, ACP-105 helps reduce high-density lipoprotein levels while increasing muscle mass. Due to its lack of aromatization, the compound does not cause elevated estrogen levels, thereby reducing water retention. ACP-105 indeed has enhanced potency and stronger anabolic effects; however, it still does not surpass the potential benefits of testosterone. Nevertheless, this makes ACP-105 much safer to use. As a partial agonist, ACP-105 does not cause the significant suppression one might expect from other SARMs. However, this does not mean post-cycle therapy (PCT) is unnecessary. It’s essential to have PCT on hand, as testosterone suppression from ACP-105 can lead to fatigue and exhaustion.
Although ACP-105 is a partial agonist, it undoubtedly delivers various benefits, all aimed at making the body stronger with minimal side effects. It works to lower high-density lipoproteins in the body, helping to increase lean mass and reduce fat. Studies suggest that ACP-105 improves cognitive function by increasing androgen receptors in the hippocampus area (3). ACP-105 also promotes muscle mass growth without causing muscle depletion, which is beneficial for treating degenerative bone diseases like osteoporosis. With ACP-105 supplementation, you can stay energetic and active for longer without feeling tired or fatigued (4). More importantly, ACP-105 is a much safer SARM option compared to other androgenic drugs. During injuries, ACP-105 can facilitate faster recovery, reducing healing time. Finally, the lack of aromatization helps reduce water retention and potential bloating. Given these benefits, it’s clear that ACP-105 offers a broad range of advantages.
When used in bodybuilding, ACP-105 functions similarly to other selective androgen receptor modulators (SARMs). It works by selectively attaching to androgen receptors found in skeletal muscles, promoting increases in both muscle mass and endurance.
The compound’s mechanism involves targeted interaction with androgen receptors, avoiding unnecessary impact on vital organs. This specificity not only enhances muscle development but also contributes to the overall efficiency and safety of the bodybuilding process. By adhering to prescribed dosages and recommended cycle durations, individuals can expect positive effects from ACP-105 on muscle growth and endurance. Notably, despite similarities with other SARMs, ACP-105’s distinct characteristics and favorable anabolic effects position it as a noteworthy supplement in the bodybuilding realm. As with any performance-enhancing substance, prudent use, adherence to recommended guidelines, and awareness of potential side effects remain critical for individuals incorporating ACP-105 into their fitness regimen.
In the context of ACP-105 use, adhering to the recommended cycle duration is crucial for achieving optimal results. Typically, a cycle lasting 8 to 13 weeks is advised for individuals incorporating ACP-105 into their fitness regimen. This timeframe is strategically designed to balance the compound’s potential benefits with the need for periodic breaks to mitigate any potential side effects or tolerance buildup.
Notably, women are specifically recommended to follow a modified dosage and cycle duration. For women, the recommended daily dose is reduced to 5 mg, and the cycle duration is shortened to 6–8 weeks. This tailored approach accounts for physiological differences between sexes and aims to optimize ACP-105’s positive effects while minimizing any associated risks.
The saying “no pain, no gain” surprisingly holds true even in the case of ACP-105 supplementation. Despite being a highly potent partial agonist, it can still expose you to certain undesirable side effects.
Initial use of ACP-105 supplements may be accompanied by mild headaches, which typically subside quickly if the recommended ACP-105 dose is followed. With increased doses, headaches may become more severe and require medical attention. Additionally, after seven to eight weeks of starting ACP-105, your body may begin to experience fatigue and exhaustion. This is a sign of testosterone suppression from prolonged ACP-105 use. To address this, post-cycle therapy (PCT) is recommended to help the body recover.
One of the best ways to determine whether a product you plan to use is authentic or has potential side effects that could be harmful to your health is to pay attention to user experiences.
Similarly, for ACP-105, we’ve gathered some customer feedback that can help you make a more informed decision.
One user mentions:
“Strength gains were better than I expected, considering I was in a significant calorie deficit. No water retention. This is probably the best compound for cutting if side effects are your main concern.”
Another writes, comparing ACP-105 to Ostarine:
“From my experience, ACP was more suppressive than Osta, but on the flip side, ACP had little impact on lipids and liver enzymes. Osta was much harsher on lipids and liver for me.”
Another mentions:
“The only downside is that it’s more suppressive.”
From these reviews, it’s clear that ACP-105 is indeed one of the most effective SARMs, though it can be somewhat more suppressive compared to others.
While ACP-105 alone can work wonders for the body, combining it with other SARMs can undoubtedly be the cherry on top.
For Cutting, Recommended:
ACP-105 (10 mg/day) + Ostarine (25 mg/day) + Cardarine (10 mg/day)
If you’re looking for the best stack for cutting!
Since all these SARMs likely follow a fairly similar mechanism of action, using this stack means you can reduce unwanted body fat while increasing muscle mass, making you look physically better.
For Bulking, Recommended:
ACP-105 (10 mg/day) + Ligandrol (20 mg/day) + YK-11 (10 mg/day):
If you want quick results with increased muscle mass and volume, using this stack will help.
With this stack, you can gain significant muscle mass while adapting to a high-calorie diet.
Ostarine, like ACP-105, is a SARM initially introduced to the market to prevent muscle wasting and treat degenerative bone diseases like osteoporosis.
However, Ostarine outperforms ACP-105 in several aspects, such as:
RAD-140, like ACP-105, is arguably the most potent anabolic compound available, significantly increasing muscle mass.
It helps boost muscle mass gains, strength, and unwanted fat loss within 6–8 weeks of supplementation.
RAD-140 also has minimal side effects compared to anabolic steroids.
Interestingly, RAD-140 acts like a pump, causing muscles to retain more water, making them appear fuller and healthier.
S4, widely known as Andarine, is one of the most potent SARMs used by bodybuilders during the cutting phase.
This SARM helps effectively reduce fat loss, allowing the body to shed excess fat.
However, according to some sources, S4 has more side effects compared to other supplements.
Yes, ACP-105 is a selective androgen receptor modulator (SARM). However, unlike other SARMs, ACP-105 is a partial agonist rather than a full one.
Can ACP-105 Be Used in People with Diabetes?
Some users have claimed that ACP-105 supplementation improved blood sugar levels. However, there is little scientific evidence to support this. Therefore, it’s crucial to consult your doctor before making any decisions.
Do I Need PCT with ACP-105?
Yes! You will need post-cycle therapy (PCT) when using ACP-105. ACP-105 can suppress testosterone levels after 6–8 weeks of a cycle, leading to fatigue and nausea. To combat this, your body will require PCT to recover.
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